Your blood is a wilderness of diverse cellular life. The plasma, which is essentially water and some proteins, carries cells to their destination. The essential functions of these cells are critical to human life.
Among them are PBMC cells. Without them, the necessary process of evolution could not occur.
Keep reading to discover the importance of PBMC cells.
What Are PBMC’s?
Peripheral blood mononuclear cells are a collection of cells that keep your body healthy and recover from illnesses. PBMC for short.
When bacteria or viruses enter the body they are marked so that immune cells can find them. When these cells find them, they stick to them so that Natural Kill cells can destroy them. They also get rid of damaged or malfunctioning cells. Cancer cells are an example of these.
Cells multiple naturally but sometimes they multiply too many times. When the body starts to see this, these cells are marked to be destroyed. In a healthy process, these cells are killed and removed from the body. These cells become cancerous when the body cannot stop the cells from multiplying.
The break down of this natural cellular process is what doctors and nutritionists hope to help patients avoid. It’s why there is always a new ‘superfood’ on the market. It is one process in millions that occur in the body but it is one of the most vital.
How Are PBMC Cells Used in Research?
The study of PBMCs gives medical professionals a clearer view of how the body responds to disease. Researchers use their findings in areas including but not limited to transplant therapy, vaccine development, and toxicology. This research opens up possibilities for treating cancer in individuals with high mortality rates.
How are PBMCs Isolated?
PBMCs come from donors of many descriptions. Because these cells are used for research, the donors are either healthy or infected with a disease.
A PBMC fraction from a person with tuberculosis, for example, would aid in researching how the cells respond to the illness.
There are two main processes for isolating PBMCs from the blood. One method exploits the different densities of the cells. This is called the density gradient centrifugation process. Blood is layered on top or below a density gradient medium.
The sample is then put through centrifugation. The result is the separated layers of plasma, blood cells, and PBMC.
Another method, called leukapheresis, uses a leukapheresis machine to separate the cells from a blood sample. A high-speed centrifugation machine separates out the PBMCs and returns the rest of the blood back to the donor. On average this process produces several times more immune cells than the gradient medium method.
It is important to note that the method of extraction effects the cells and how well they function in an isolated environment.
The blood that flows through our bodies carries with it centuries of finely evolved processes. Through the study of PBMC cells, researchers come a step closer to understanding how our bodies are affected by the world around us. It can help people live more enriched lives with transplants. It can offer more information on how to reduce the negative side effects of prescription drugs.
Understanding peripheral blood mononuclear cells put doctors a step closer to a healthier society.
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