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Gen-Probe Reports Financial Results for the Fourth Quarter of 2011

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SAN DIEGO, Feb. 13, 2012 /PRNewswire/ -- Gen-Probe Incorporated (NASDAQ: GPRO) today reported financial results for the fourth quarter of 2011. Total revenues in the quarter grew 16%, to a new record of $158.2 million, while non-GAAP earnings per share (EPS) increased 18%, to a new high of $0.72.

"Gen-Probe finished 2011 strong, as blood screening sales rebounded in the fourth quarter while clinical diagnostics revenues continued their solid growth," said Carl Hull, the Company's chairman and chief executive officer. "We enter 2012 with excellent momentum based on several new product launches that are off to good starts."


    Key financial results for the fourth quarter of 2011 were
     ($ in millions, except EPS):

                                     Non-GAAP                           GAAP
                                     --------                           ----
                             2011       2010    Change          2011   2010  Change
                             ----       ----    ------          ----   ----  ------
    Total revenues         $158.2     $136.7        +16%      $158.2 $136.7      +16%
    Product sales          $155.2     $131.1        +18%      $155.2 $131.1      +18%
    Operating profit        $45.8      $40.1        +14%       $29.4  $36.8      -20%
    Net income              $33.7      $29.4        +15%       $19.9  $27.2      -27%
    EPS                     $0.72      $0.61        +18%       $0.42  $0.56      -25%


Gen-Probe's GAAP results for the fourth quarter of 2011 were negatively affected by impairment charges of $12.7 million related to acquired goodwill and intangible assets.

Revenue Detail

In the fourth quarter of 2011, clinical diagnostics product sales grew by 13% compared to the prior year period. This increase was driven primarily by domestic and international growth of the APTIMA Combo 2® assay for detecting Chlamydia and gonorrhea, and by the inclusion of sales from the former GTI Diagnostics (GTI), which the Company acquired in December of 2010. Foreign currency fluctuations reduced clinical diagnostics sales by an estimated $0.1 million compared to the prior year period.

In blood screening, fourth-quarter sales increased by 30% compared to the prior year period, as expected, mainly due to greater shipments of assays and TIGRIS® instruments to Novartis, the Company's blood screening collaboration partner. Foreign currency fluctuations increased blood screening sales by an estimated $0.2 million compared to the prior year period.

Sales of research products and services in the fourth quarter of 2011 were $2.4 million, down 29% compared to the prior year period. Foreign currency fluctuations had an immaterial effect on sales of research products and services compared to the prior year period.


    Fourth quarter product sales were ($ in millions):

                           Three Months Ended Dec. 31,            Change
                           ---------------------------            ------
                                  2011           2010     As          Constant
                                  ----           ----  Reported       Currency
                                                       --------       --------
    Clinical
     Diagnostics                 $90.6          $80.1         +13%           +13%
    Blood Screening              $62.1          $47.6         +30%           +30%
    Research Products             $2.4           $3.4         -29%           -29%
    -----------------             ----           ----         ---            ---
    and Services
    ------------
    Total Product Sales         $155.2         $131.1         +18%           +18%


Collaborative research revenues in the fourth quarter of 2011 were $1.4 million, compared to $3.7 million in the prior year period, a decrease of 62% that resulted primarily from an expected decrease in funding from Novartis associated with the development of the fully automated PANTHER® instrument for the blood screening market. The PANTHER system remains on track to be launched into international blood screening markets this year.

Royalty and license revenues in the fourth quarter of 2011 were $1.6 million, compared to $1.9 million in the prior year period, a decrease of 16%.

GAAP Income Statement Details

Gross margin on product sales was 66.7% in the fourth quarter of 2011, compared to 69.4% in the prior year period. This decrease resulted mainly from higher sales of low-margin instrumentation to Novartis, which are generally a precursor to future assay sales.

Acquisition-related amortization expenses were $2.8 million in the fourth quarter of 2011, compared to $2.2 million in the prior year period, an increase of 27% that resulted mainly from the acquisition of GTI.

Research and development (R&D) expenses were $28.2 million in the fourth quarter of 2011, compared to $26.9 million in the prior year period, an increase of 5% that resulted primarily from the addition of GTI's R&D programs.

Marketing and sales expenses were $17.1 million in the fourth quarter of 2011, compared to $15.0 million in the prior year period, an increase of 14% that resulted primarily from the addition of GTI's cost structure and ongoing European commercial expansion.

General and administrative (G&A) expenses were $16.2 million in the fourth quarter of 2011, compared to $15.6 million in the prior year period, an increase of 4% that resulted mainly from the addition of GTI's cost structure.

Goodwill and asset impairment charges totaled $12.7 million in the fourth quarter of 2011. Of this charge, $8.7 million related to goodwill associated with the Company's research products and services business, which was acquired as part of the Tepnel acquisition in April of 2009, and $4.0 million related to in-process research and development intangible assets of GTI.

Total other income, net, was $0.4 million in the fourth quarter of 2011, compared to total other income, net, of $1.2 million in the prior year period, a decrease of 67%. This decrease resulted primarily from a non-cash gain in the prior year period and unfavorable exchange rate effects.

Income tax expense was $10.0 million in the fourth quarter of 2011, corresponding to an effective tax rate of 33%.

Non-GAAP Income Statement Details

In the fourth quarter of 2011, non-GAAP gross margin on product sales, R&D expenses, marketing and sales expenses, and total other income, net, were similar to the corresponding GAAP results.

Excluding transaction-related expenses and restructuring costs, non-GAAP G&A expenses were $15.6 million in the fourth quarter of 2011, compared to $14.7 million in the prior year period, an increase of 6%.

Non-GAAP income tax expense was $12.4 million in the fourth quarter of 2011, corresponding to an effective tax rate of 27%. Income tax expense was less than expected in the fourth quarter due to the utilization of foreign losses and higher ex-US sales.

Cash Flows and Balance Sheet

In the fourth quarter of 2011, Gen-Probe generated net cash of $53.4 million from operating activities, and spent $7.2 million on property, plant and equipment, leading to free cash flow of $46.2 million, a new quarterly record.

Gen-Probe continues to maintain a strong balance sheet. As of December 31, 2011, the Company had $368.0 million of cash, cash equivalents and marketable securities, and $248.0 million of short-term debt. The Company pays interest on this debt at a rate 0.6% above the one-month London Interbank Offered Rate (LIBOR), which was recently below 0.3%.

During the fourth quarter of 2011, Gen-Probe repurchased 1.7 million shares of Company stock for $100 million, corresponding to an average purchase price of $58.83 per share. This completed the $100 million repurchase plan that was announced in November of 2011.

2012 Financial Guidance

"We anticipate returning to low double-digit organic revenue growth in 2012 based on multiple new product launches that are still in their early stages," said Herm Rosenman, Gen-Probe's senior vice president, finance, and chief financial officer. "We forecast a similar rate of bottom-line growth in 2012 as we invest in these launches and in a series of R&D projects that extend our lead in assay and instrument performance. We believe that these investments position us well for solid, sustainable growth over the next several years."

Gen-Probe's 2012 financial guidance is provided below:




                                   Non-GAAP               GAAP
                                   --------               ----
    Total revenues           $630 to $655 million $630 to $655 million
    Product gross margins            68% to 69.5%        68% to 69.5%
    Acquisition-related
     amortization,                            N/A     ~ $15 million
     restructuring and other
      transaction
     expense
    Operating margin                 26.5% to 28%        24.5% to 26%
    Tax rate                       30.5% to 32.5%      30.5% to 32.5%
    Diluted shares               ~ 47 million         ~ 47 million
    EPS                            $2.50 to $2.68       $2.30 to $2.48


About Non-GAAP Financial Measures

Gen-Probe's management believes that non-GAAP financial measures provide meaningful supplemental information regarding the Company's performance by excluding certain expenses and other items that may not be indicative of core business results. To supplement the Company's financial results for the fourth quarter of 2011 and its 2012 financial guidance, in each case presented in accordance with GAAP, Gen-Probe uses the following financial measures defined as non-GAAP by the SEC: non-GAAP net income, non-GAAP gross margin, non-GAAP R&D expenses, non-GAAP marketing and sales expenses, non-GAAP G&A expenses, non-GAAP operating profit, non-GAAP income tax rate, and non-GAAP EPS. Gen-Probe's management does not, nor does it suggest that investors should, consider such non-GAAP financial measures in isolation from, or as a substitute for, financial information prepared and presented in accordance with GAAP. Gen-Probe believes that both management and investors benefit from referring to these non-GAAP financial measures in assessing Gen-Probe's performance and when planning, forecasting and analyzing future periods. These non-GAAP financial measures also facilitate management's internal comparisons to Gen-Probe's historical performance and our competitors' operating results. Gen-Probe believes these non-GAAP financial measures are useful to investors in allowing for greater transparency with respect to supplemental information used by management in its financial and operational decision making. Further, our reconciliations of non-GAAP to GAAP operating results, which are included on the attached tables, are presented in the format of consolidated statements of income solely to assist a reader in understanding the impact of the various adjustments to our GAAP operating results, individually and in the aggregate, and are not intended to place any undue prominence on our non-GAAP operating results.

Notes on Presentation

In this news release, all per share amounts are calculated on a diluted basis. Some totals may not foot due to rounding. Certain prior year amounts have been reclassified to conform to the current year presentation.

Webcast Conference Call

A live webcast of Gen-Probe's fourth quarter 2011 conference call for investors can be accessed at http://www.gen-probe.com beginning at 4:30 p.m. Eastern Time today. The webcast will be archived for at least 90 days. A telephone replay of the call also will be available for approximately 24 hours. Call 866-501-7043 (domestic) or 203-369-1846 (international).

About Gen-Probe

Gen-Probe is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective molecular diagnostic products and services that are used primarily to diagnose human diseases, screen donated human blood, and ensure transplant compatibility. Gen-Probe is headquartered in San Diego and employs approximately 1,400 people. For more information, go to www.gen-probe.com.

Trademarks

APTIMA, APTIMA COMBO 2, PANTHER and TIGRIS are trademarks of Gen-Probe. All other trademarks are the property of their owners.

Caution Regarding Forward-Looking Statements

Any statements in this news release about our expectations, beliefs, plans, objectives, assumptions or future events or performance, including those under the heading "2012 Financial Guidance," are not historical facts and are forward-looking statements. These statements are often, but not always, made through the use of words or phrases such as believe, will, expect, anticipate, estimate, intend, plan and would. For example, statements concerning Gen-Probe's financial condition, possible or expected results of operations, the development and commercialization of new products, regulatory approvals, future milestones, growth opportunities, market trends, and management plans are forward-looking statements. Forward-looking statements are not guarantees of performance. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, levels of activity, performance or achievements to differ materially from those expressed or implied. Some of these risks, uncertainties and assumptions include but are not limited to: (i) the risk that we may not achieve our expected 2012 financial targets, (ii) the risk that we may not integrate acquisitions, such as Tepnel, Prodesse and GTI, successfully, (iii) the possibility that the market for the sale of our new products, such as our PANTHER system and PROGENSA PCA3, APTIMA HPV and APTIMA trichomonas assays, may not develop as expected, (iv) the enhancement of existing products and the development of new products may not proceed as planned, (v) the risk that investigational products, including those now in US clinical trials, may not be approved by regulatory authorities or become commercially available in the time frame we anticipate, or at all, (vi) the risk that we may not be able to compete effectively, (vii) the risk that we may not be able to maintain our current corporate collaborations or enter into new ones, (viii) our dependence on Novartis and other third parties for the distribution of some of our products, (ix) our dependence on a small number of customers, contract manufacturers and single source suppliers of raw materials, (x) changes in third-party reimbursement policies regarding our products could adversely affect sales, (xi) changes in government regulation or tax policy affecting our diagnostic products could harm our sales, increase our development costs or increase our taxes, (xii) the risk that our intellectual property may be infringed or invalidated, and (xiii) our involvement in patent and other intellectual property and commercial litigation could be expensive and could divert management's attention. This list includes some, but not all, of the factors that could affect our ability to achieve results described in forward-looking statements. For additional information about risks and uncertainties we face and a discussion of our financial statements and footnotes, see documents we file with the SEC, including our most recent annual report on Form 10-K and all subsequent periodic reports. We assume no obligation and expressly disclaim any duty to update forward-looking statements to reflect events or circumstances after the date of this news release or to reflect the occurrence of subsequent events.

Contact:

Michael Watts
Vice president, investor relations and
corporate communications
858-410-8673


                                   Gen-Probe Incorporated
                             Consolidated Balance Sheets - GAAP
                      (In thousands, except share and per share data)

                                                       December 31,   December 31,
                                                               2011           2010
                                                               ----           ----
    Assets                                             (Unaudited)
    Current assets:
      Cash and cash equivalents, including
       restricted cash of $38 and $16 at
       December 31, 2011 and December 31,
       2010, respectively                                   $87,021        $59,690
      Marketable securities                                 218,789        170,648
      Trade accounts receivable, net of
       allowance for doubtful accounts of $320
       and $355 at December 31, 2011 and
       December 31, 2010, respectively                       57,767         54,739
      Accounts receivable - other                             3,446          5,493
      Inventories                                            77,886         66,416
      Deferred income tax                                     8,188         13,634
      Prepaid expenses                                       11,555         14,665
      Other current assets                                    4,967          5,148
                                                              -----          -----
    Total current assets                                    469,619        390,433
    Marketable securities, net of current
     portion                                                 62,237        259,317
    Property, plant and equipment, net                      176,081        160,863
    Capitalized software, net                                16,992         13,981
    Patents, net                                             11,758         12,450
    Goodwill                                                140,404        150,308
    Purchased intangibles, net                              106,619        120,270
    License, manufacturing access fees and
     other assets, net                                       61,738         60,175
    Total assets                                         $1,045,448     $1,167,797
                                                         ==========     ==========

    Liabilities and stockholders' equity
    Current liabilities:
      Accounts payable                                      $12,000        $14,614
      Accrued salaries and employee benefits                 28,795         26,825
      Other accrued expenses                                 12,846         13,935
      Income tax payable                                      1,857            634
      Short-term borrowings                                 248,000        240,000
      Deferred revenue                                        1,238          1,166
                                                              -----          -----
    Total current liabilities                               304,736        297,174
    Non-current income tax payable                           10,019          8,315
    Deferred income tax                                      19,283         29,775
    Deferred revenue, net of current portion                  3,237          2,500
    Other long-term liabilities                               7,831          6,654
    Commitments and contingencies
    Stockholders' equity:
      Preferred stock, $0.0001 par value per
       share; 20,000,000 shares authorized,
       none issued and outstanding                                -              -
      Common stock, $0.0001 par value per
       share; 200,000,000 shares authorized,
       45,008,879 and 47,966,156 shares issued
       and outstanding at December 31, 2011
       and December 31, 2010, respectively                        5           5
      Additional paid-in capital                             23,650        195,820
      Accumulated other comprehensive income
       (loss)                                                  (313)           678
      Retained earnings                                     677,000        626,876
    Total stockholders' equity                              700,342        823,379
                                                            -------        -------
    Total liabilities and stockholders'
     equity                                              $1,045,448     $1,167,797
                                                         ==========     ==========



                               Gen-Probe Incorporated
                      Consolidated Statements of Income - GAAP
                        (In thousands, except per share data)
                                     (Unaudited)

                              Three Months Ended                 Twelve Months Ended
                                 December 31,                        December 31,
                                 ------------                        ------------
                               2011             2010             2011             2010
                               ----             ----             ----             ----
    Revenues:
       Product
       sales               $155,162         $131,093         $562,588         $522,709
       Collaborative
       research
       revenue                1,369            3,708            7,682           14,518
       Royalty
       and
       license
       revenue                1,644            1,893            5,964            6,100
                              -----            -----            -----            -----
     Total
     revenues               158,175          136,694          576,234          543,327

    Operating
     expenses:
       Cost
       of
       product
       sales
       (excluding
       acquisition-
       related
       intangible
       amortization)         51,742         40,104        173,645        169,222
       Acquisition-
       related
       intangible
       amortization           2,760            2,231           11,061            8,847
       Research
       and
       development           28,202           26,885          112,742          111,103
       Marketing
       and
       sales                 17,056           15,016           68,396           59,492
       General
       and
       administrative        16,240           15,610           71,394           56,818
       Goodwill
       and
       asset
       impairment
       charges               12,746              -         12,746              -
                             ------              ---           ------              ---
     Total
     operating
     expenses               128,746           99,846          449,984          405,482
                            -------           ------          -------          -------
     Income
     from
     operations              29,429           36,848          126,250          137,845
    Other income
     (expense):
       Investment
       and
       interest
       income                 1,317            1,401            8,695           11,765
       Interest
       expense                 (546)            (535)          (2,070)          (2,216)
       Gain
       on
       contingent
       consideration              -              399                -            7,994
       Other-
       than-
       temporary
       impairment
       loss
       on
       equity
       investment                 -              -        (39,482)             -
       Other
       income
       (expense),
       net                     (364)             (95)            (236)            (177)
                               ----              ---             ----             ----
     Total
     other
     income
     (expense),
     net                        407          1,170        (33,093)        17,366
                                ---            -----          -------           ------

     Income
     before
     income
     tax                     29,836           38,018           93,157          155,211
     Income
     tax
     expense                  9,977           10,780           43,033           48,274
     Net
     income                 $19,859          $27,238          $50,124         $106,937
                            =======          =======          =======         ========

    Net income per
     share:
      Basic                   $0.43            $0.57            $1.06            $2.20
                              =====            =====            =====            =====
      Diluted                 $0.42            $0.56            $1.04            $2.18
                              =====            =====            =====            =====

    Weighted
     average
     shares
     outstanding:
      Basic                  46,117           47,827           47,254           48,560
                             ======           ======           ======           ======
      Diluted                46,944           48,455           48,387           49,033
                             ======           ======           ======           ======



                                           Gen-Probe Incorporated
                        Consolidated Statements of Income - Non-GAAP Reconciliations
                                    (In thousands, except per share data)
                                                 (Unaudited)

                                      Three Months Ended                       Three Months Ended
                                       December 31, 2011                        December 31, 2010
                                       -----------------                        -----------------
                              Non-GAAP    Adjustments     GAAP         Non-GAAP    Adjustments     GAAP
                              --------    -----------     ----         --------    -----------     ----
    Revenues:
      Product
       sales                   $155,162            $-    $155,162       $131,093            $-    $131,093
       Collaborative
       research
       revenue                    1,369             -       1,369          3,708             -       3,708
      Royalty
       and
       license
       revenue                    1,644             -       1,644          1,893             -       1,893
                                  -----           ---       -----          -----           ---       -----
    Total
     revenues                   158,175             -     158,175        136,694             -     136,694

    Operating expenses:
      Cost of
       product
       sales
       (excluding
       acquisition-
       related
       intangible
       amortization)             51,626           116      51,742       40,013            91      40,104
       Acquisition-
       related
       intangible
       amortization                   -         2,760       2,760              -         2,231       2,231
      Research
       and
       development               28,160            42      28,202         26,885             -      26,885
       Marketing
       and
       sales                     17,042            14      17,056         15,016             -      15,016
      General
       and
       administrative            15,570           670      16,240         14,670           940      15,610
      Goodwill
       and
       asset
       impairment
       charges                        -        12,746      12,746            -             -           -
                                                  ---                                      ---
    Total
     operating
     expenses                   112,398        16,348     128,746         96,584         3,262      99,846
                                -------        ------     -------         ------         -----      ------
    Income
     from
     operations                  45,777       (16,348)     29,429         40,110        (3,262)     36,848
    Other income
     (expense):
       Investment
       and
       interest
       income                     1,317             -       1,317          1,401             -       1,401
      Interest
       expense                     (546)            -        (546)          (535)            -        (535)
      Gain on
       contingent
       consideration                  -             -           -              -           399         399
      Other
       income
       (expense),
       net                         (364)            -        (364)           (95)            -         (95)
                                   ----           ---        ----            ---           ---         ---
    Total
     other
     income,
     net                            407             -         407            771           399       1,170
                                    ---           ---         ---            ---           ---       -----

                                 46,184       (16,348)     29,836         40,881        (2,863)     38,018
    Income before
     income tax
    Income
     tax
     expense                     12,441        (2,464)      9,977         11,437          (657)     10,780
    Net
     income                     $33,743      $(13,884)    $19,859        $29,444       $(2,206)    $27,238
                                =======      ========     =======        =======       =======     =======

    Net income per
     share:
      Basic                       $0.73        $(0.30)      $0.43          $0.61        $(0.04)      $0.57
                                  =====        ======       =====          =====        ======       =====
      Diluted                     $0.72        $(0.30)      $0.42          $0.61        $(0.05)      $0.56
                                  =====        ======       =====          =====        ======       =====

    Weighted average
     shares
     outstanding:
      Basic                      46,117                    46,117         47,827                    47,827
                                 ======                    ======         ======                    ======
      Diluted                    46,944                    46,944         48,455                    48,455
                                 ======                    ======         ======                    ======



                                           Gen-Probe Incorporated
                        Consolidated Statements of Income - Non-GAAP Reconciliations
                                    (In thousands, except per share data)
                                                 (Unaudited)

                                      Twelve Months Ended                      Twelve Months Ended
                                       December 31, 2011                        December 31, 2010
                                       -----------------                        -----------------
                              Non-GAAP    Adjustments     GAAP         Non-GAAP    Adjustments     GAAP
                              --------    -----------     ----         --------    -----------     ----
    Revenues:
      Product
       sales                   $562,588            $-    $562,588       $522,709            $-    $522,709
       Collaborative
       research
       revenue                    7,682             -       7,682         14,518             -      14,518
      Royalty
       and
       license
       revenue                    5,964             -       5,964          6,100             -       6,100
                                  -----           ---       -----          -----           ---       -----
    Total
     revenues                   576,234             -     576,234        543,327             -     543,327

    Operating expenses:
      Cost of
       product
       sales
       (excluding
       acquisition-
       related
       intangible
       amortization)            173,216           429     173,645      168,860           362     169,222
       Acquisition-
       related
       intangible
       amortization                   -        11,061      11,061              -         8,847       8,847
      Research
       and
       development              112,633           109     112,742        111,103             -     111,103
       Marketing
       and
       sales                     68,359            37      68,396         59,492             -      59,492
      General
       and
       administrative            66,170         5,224      71,394         54,491         2,327      56,818
      Goodwill
       and
       asset
       impairment
       charges                        -        12,746      12,746            -             -           -
                                                  ---                                      ---
    Total
     operating
     expenses                   420,378        29,606     449,984        393,946        11,536     405,482
                                -------        ------     -------        -------        ------     -------
    Income
     from
     operations                 155,856       (29,606)    126,250        149,381       (11,536)    137,845
    Other income
     (expense):
       Investment
       and
       interest
       income                     8,695             -       8,695         11,765             -      11,765
      Interest
       expense                   (2,070)            -      (2,070)        (2,216)            -      (2,216)
      Gain on
       contingent
       consideration                  -             -           -              -         7,994       7,994
      Other-
       than-
       temporary
       impairment
       loss on
       equity
       investment                     -       (39,482)    (39,482)           -             -           -
      Other
       income
       (expense),
       net                         (236)            -        (236)          (177)            -        (177)
    Total
     other
     income
     (expense),
     net                          6,389       (39,482)    (33,093)       9,372         7,994      17,366
                                  -----       -------     -------          -----         -----      ------

    Income
     before
     income
     tax                        162,245       (69,088)     93,157        158,753        (3,542)    155,211
    Income
     tax
     expense                     49,226        (6,193)     43,033         51,303        (3,029)     48,274
    Net
     income                    $113,019      $(62,895)    $50,124       $107,450         $(513)   $106,937
                               ========      ========     =======       ========         =====    ========

    Net income per
     share:
      Basic                       $2.39        $(1.33)      $1.06          $2.21        $(0.01)      $2.20
                                  =====        ======       =====          =====        ======       =====
      Diluted                     $2.34        $(1.30)      $1.04          $2.19        $(0.01)      $2.18
                                  =====        ======       =====          =====        ======       =====

    Weighted average
     shares
     outstanding:
      Basic                      47,254                    47,254         48,560                    48,560
                                 ======                    ======         ======                    ======
      Diluted                    48,387                    48,387         49,033                    49,033
                                 ======                    ======         ======                    ======



                                   Gen-Probe Incorporated
                        Consolidated Statements of Cash Flows - GAAP
                                       (In thousands)
                                        (Unaudited)

                                                              Twelve Months Ended
                                                                  December 31,
                                                                  ------------
                                                                2011             2010
                                                                ----             ----
    Operating activities:
    Net income                                               $50,124         $106,937
    Adjustments to reconcile net income to net cash
     provided by operating activities:
      Depreciation and amortization                           46,569           44,529
      Amortization of premiums on
       investments, net of accretion of
       discounts                                               9,592            9,573
      Stock-based compensation                                24,741           24,075
      Excess tax benefit from employee
       stock-based compensation                               (5,080)          (3,692)
      Deferred revenue                                           850           (1,808)
      Deferred income tax                                     (4,220)          (3,745)
      Other-than-temporary impairment
       loss on equity investment                              39,482                -
      Goodwill and asset impairment charges                   12,746                -
      Gain on contingent consideration                             -           (7,994)
      Loss on disposal of property and
       equipment                                                 364            1,065
      Changes in assets and liabilities:
       Trade and other accounts receivable                    (1,112)           2,649
       Inventories                                           (11,168)          (1,154)
       Prepaid expenses                                          408            3,055
       Other current assets                                      384             (360)
       Other long-term assets                                  7,164             (559)
       Accounts payable                                       (2,698)          (6,265)
       Accrued salaries and employee
        benefits                                               2,981             (133)
       Other accrued expenses                                 (1,398)          (4,417)
       Income tax payable                                     10,313            7,688
       Other long-term liabilities                             1,211              122
    Net cash provided by operating
     activities                                              181,253          169,566
                                                             -------          -------

    Investing activities:
    Proceeds from sales and maturities of
     marketable securities                                   489,241          427,821
    Purchases of marketable securities                      (395,190)        (401,434)
    Purchases of property, plant and
     equipment                                               (41,664)         (30,716)
    Purchase of capitalized software                          (6,053)          (3,891)
    Purchases of intangible assets,
     including licenses and manufacturing
     access fees                                              (5,259)          (2,513)
    Net cash paid for business
     combinations                                                  -          (53,000)
    Cash paid for investment in Roka
     Bioscience                                               (3,980)               -
    Cash paid for investment in Pacific
     Biosciences                                                   -          (50,000)
    Other                                                       (209)            (738)
    Net cash provided by (used in)
     investing activities                                     36,886         (114,471)
                                                              ------         --------

    Financing activities:
    Repurchase and retirement of common
     stock                                                  (250,000)         (99,935)
    Proceeds from issuance of common
     stock and employee stock purchase
     plan                                                     49,932           31,830
    Payment of contingent consideration                            -          (10,000)
    Repurchase and retirement of
     restricted stock for payment of
     taxes                                                    (1,615)          (1,257)
    Excess tax benefit from employee
     stock-based compensation                                  5,080            3,692
    Borrowings, net                                            8,000             (228)
    Net cash used in financing activities                   (188,603)         (75,898)
                                                            --------          -------
    Effect of exchange rate changes on
     cash and cash equivalents                                (2,205)          (2,123)
                                                              ------           ------
    Net increase (decrease) in cash and
     cash equivalents                                         27,331          (22,926)
    Cash and cash equivalents at the
     beginning of period                                      59,690           82,616
    Cash and cash equivalents at the end
     of period                                               $87,021          $59,690
                                                             =======          =======


SOURCE Gen-Probe Incorporated



 
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