Protherics PLC announces Interest in Shares

Protherics PLC

Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 4 July 2008 - Protherics PLC
("Protherics" or the "Company"), the international
biopharmaceutical
company focused on critical care and cancer, announces that on 3
July 2008, in accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share
capital of
the Company was received from AXA Investment Managers UK Limited
on
behalf of AXA S.A. and its Group Companies ("AXA").  The
notification
follows a disposal of voting rights.  Details of
the interest notified are as follows:

1.  Reason for the notification (please tick the appropriate box
or
boxes)

A disposal of voting rights
X

An acquisition or disposal of financial instruments which may
result
in the acquisition of shares already issued to which voting rights
are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the AXA S.A., 25 Avenue
Matignon,
notification obligation:                 75008 Paris and its group
of
                                         companies.

3. Full name of shareholder(s) (if
different from 2.):

4. Date of the transaction (and date on  2 July 2008
which the threshold is crossed or
reached if different):

5. Date on which issuer notified:        3 July 2008

6. Threshold(s) that is/are crossed or   13%
reached:

7. Notified details:

A: Voting rights attached to shares

Class/   Situation previous to Resulting situation after the
triggering
type of  the Triggering        transaction
shares   transaction

if       Number of  Number of  Number  Number of voting   % of
voting
possible Shares     Voting     of      rights             rights
using               Rights     shares
the ISIN
CODE                          Direct  Direct  Indirect   Direct
Indirect

0702920  44,836,830 44,836,830 941,666 941,666 40,774,831 0.28%
11.98%


B: Financial Instruments

Resulting situation after the triggering transaction

Type of     Expiration Exercise/   Number of voting rights that  %
of
financial   date       Conversion  may be acquired if the
voting
instrument             Period/     instrument is exercised/
rights
                       Date        converted.


Total (A+B)

Number of voting rights % of voting rights

41,716,497              12.25%


8. Chain of controlled undertakings through which the voting
rights and
/or the financial instruments are effectively held, if applicable
:

Name of Company/Fund             Number of      % of issued share
                                 Shares         capital

AXA UK Investment Co ICVC        552,143        0.16220

UK Smaller Companies Fund

Indirect

Sun Life Pensions Management Ltd 225,000        0.06610

DirectSun Life Unit Assurance Ltd      53,913         0.01584

FTSE All Share Tracker

Direct

Sun Life Pensions Management     294,874        0.08662

FTSE All Share Tracker

Direct

AXA Framlington                  425,000        0.12485

Indirect

AXA Framlington                  1,851,468      0.54388

Indirect

AXA Framlington                  1,909,918      0.56105

Indirect

AXA Framlington                  459,865        0.13509

Indirect

AXA Framlington                  639,353        0.18781

Indirect

AXA Framlington                  15,438,453     4.53516

Indirect

AXA Framlington                  13,753,131     4.04008

Indirect

AXA Framlington                  2,000,000      0.58751

Indirect

AXA Framlington                  1,500,000      0.44064

Indirect

AXA Framlington                  500,000        0.14688

Indirect

AXA Framlington                  220,000        0.06463

Indirect

Framlington onshore private      975,500        0.28656
clients

Indirect

AXA Sun Life ith Profits Passive 226,817        0.06663

Direct

AXA Sun Life With Profits        141,062        0.04144
Passive

Direct

AXA Framlington                  550,000        0.16157

Indirect


Total Direct                     941,666        0.27662

Total Indirect                   40,774,831     11.97790


TOTAL                            41,716,497     12.25452



Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting rights:

12. Additional information:


/ Ends /


For further information please contact:

Protherics

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510

Julie Vickers, Company Secretary            +44 (0)1928 518010


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113

New York: John Capodanno                    +1 212 850 5600


Or visit  www.protherics.com

                    This information is provided by RNS
          The company news service from the London Stock Exchange

END