Published:
DNAPrint genomics' Trace Genetics Laboratory Completes Analysis of 800-Year-Old DNA Samples From Mink Island for National Park Service
DNAPrint genomics, Inc. (OTC BB: DNAG) today
announced that senior scientists from its Trace Genetics laboratory in
Richmond, Calif., have completed analysis and reports on 800-year-old
American Indian tooth samples from Mink Island, Alaska, for the National
Park Service.
"Two of the samples had an identical DNA sequence, which suggests that the
individuals could be siblings," said Dr. Ripan Malhi, Senior Research
Director of Trace Genetics. "This is a sequence commonly found in many
individuals from the Arctic and Subarctic, including the Chukchi, Siberian
Inuits, Aleuts and Athapaskan groups."
Dr. Malhi noted that the sequence is also found in individuals of Apache
and Nahua ancestry, suggesting that this lineage may have once been widely
geographically dispersed throughout North America but is now restricted to
the Arctic/Subarctic and Southwest/Mesoamerica, possibly as a result of
European contact.
Mink Island is situated between the Aleutian Mountain Range and the Gulf of
Alaska and, according to archaeological experts, has been occupied
intermittently for the past 7,000 years. Its maritime inhabitants were
limited to a narrow coastal corridor along the Gulf of Alaska.
In addition to providing clues about Mink Island's prehistory, the tests
conducted by Trace Genetics provide an innovative way for archaeologists to
manage the cultural resources found in U.S. National Parks. Retrieving
mitochondria DNA (mtDNA) from ancient remains is extremely difficult to
accomplish because it is usually degraded, resulting in a high likelihood
of contamination due to handling of the bone or tooth during extraction in
the laboratory. The Trace Genetics lab is one of a few that has the
specialized facilities, experienced mtDNA researchers, and reliable
protocols necessary to ensure accurate and reliable results.
The results of the Mink Island mtDNA analysis will be combined with
additional anthropological data to help gain insight into the life patterns
of these ancient people. Mitochondrial DNA is a useful tool for
investigating the genetic identity of human remains because it is part of
the mitochondrial genome and is found in high quantities outside of a
cell's nucleus. Each cell contains approximately 700 mitochondria resulting
in 100-1500 copies of the genome per cell in contrast to nuclear genes that
have only two copies per cell. However, if analyzed incorrectly, the high
copy number of mtDNA in a cell also make the analysis prone to false
results due to contamination.
"It really is quite an accomplishment to be able to extract and analyze DNA
from ancient tooth fragments," Dr. Malhi noted. "The Mink Island analysis
validates that Trace Genetics has the reliable lab protocols necessary to
analyze degraded DNA while retaining certainty of results."
About DNAPrint genomics, Inc.
DNAPrint genomics, Inc. (www.dnaprint.com) is a developer of genomics-based
products and services focused on drug development, pharmacogenomic
diagnostic tests, forensics technology and consumer genetic tests.
DNAPrint's family of products for the law enforcement forensics and
consumer markets include DNAWitness(TM) RETINOME(TM) (a predictive test for
inferring eye color from a DNA sample), ANCESTRYbyDNA(TM), and
EURO-DNA(TM). Recently announced and as a part of the Company's Trace
Genetics acquisition, DNAWitness-Y and DNAWitness-Mito are two new tests
that can be used as an identification tool when other DNA testing either
fails to yield results or the sample might be too deteriorated. The
Company's first theranostic product (drug/test combination) is PT-401, a
"Super EPO" (erythropoietin) dimer protein drug for treatment of anemia in
renal dialysis patients (end stage renal disease). Currently in
pre-clinical development, PT-401 will be targeted to patients with a
genetic profile indicating their propensity to have the best clinical
response
Forward-Looking Statements
All statements in this press release that are not historical are
forward-looking statements. Such statements are subject to risks and
uncertainties that could cause actual results to differ materially from
those projected, including, but not limited to, uncertainties relating to
technologies, product development, manufacturing, market acceptance, cost
and pricing of DNAPrint's products, dependence on collaborations and
partners, regulatory approvals, competition, intellectual property of
others, and patent protection and litigation. DNAPrint genomics, Inc.
expressly disclaims any obligation or undertaking to release publicly any
updates or revisions to any forward-looking statements contained herein to
reflect any change in DNAPrint's expectations with regard thereto or any
change in events, conditions, or circumstances on which any such statements
are based.
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